柴田　政廣
生命科学科 (システム理工学部)
教授
システム生理学研究室
■専門分野
医用生体工学、システム循環生理学、再生医療
■研究の内容
■研究室分野キーワード
組織工学的再生組織をはじめ、医療・福祉機器は、実験室（試験管）内で、どれほど高度な機能を有していたとしても、身体が受け入れてくれなければ何の役にも立ちません。本研究室では、身体の仕組みを理解し、その仕組みを利用することにより、身体に優しい再生医療・福祉工学技術の開発を目指しています。これまで客観的評価が難しかった健康度や老化度などを、先端技術を用いた生体工学的手法により定量的な指標として提供します。
バイオ・生命科学・福祉機器
■教員研究テーマ
①微小循環のバイオメカニクス（微小血管の仕事とエネルギー消費）　②毛細血管血流の可視化　③機能的血管化組織の再生
■研究室テーマ
生体に関連した「機器・材料開発」「計測」「解析」
■相談可能な分野
■保有機器
■研究室のスタンス
末梢循環機能評価
皮膚の健康度評価
食品・薬品の微小循環への影響度評価
毛細血管血流のイメージング装置
■主な著書
  • からだと酸素の事典(pp. 142-144,pp. 288-289)（2009/09 朝倉書店刊行）
  • ME教科書シリーズ「循環系のバイオメカニクス」（日本生体威工学会編）（2005/11 コロナ社刊行 p.128～155）
■主な論文
  • Oxygen dynamics in microcirculation of skeletal muscle（2014/09 IFMBE Proceedings）
  • Alteration of the Systemic and Microcirculation by a Single Oral Dose of Flavan-3-Ols（2014/04 PLoS ONE）
  • Flavan-3-ols fraction from cocoa powder promotes mitochondrial biogenesis in skeletal muscle in mice（2014/04 Lipids in Health and Disease）
  • Evaluation of vascular wall elasticity of human digital arteries using alternating current signal photoplethysmography（2013/04 Vascular Health and Risk Management）
  • Ingestion of cocoa ameliorates endothelial dysfunction in mesentery arterioles induced by high fat diet in rats: An in vivo intravital microscopy study（2012/04 Life Sciences）
  • Simulation of Vascular Volume Pulsation of Radial Index Artery（2011/09 Eur Modeling & Simulation）
  • A new proposal of tailored bioinstrumentation using rapid A new proposal of tailored bioinstrumentation using rapid prototyping and three-dimensional CAD--first trial to develop individually designed cuff-units for continuous blood pressure measurement.（2011/08 IEEE Eng Med Biol Soc）
  • Observation of capillary flow in human skin during tissue compression using CCD video-microscopy（2010/04 IEEE Eng Med Biol Soc）
  • 下腿潰瘍に対する踵・下腿用体圧分散用具の有用性の検討（2010/04 日本褥瘡学会誌）
  • Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis（2009/04 IFMBE Proceedings）
  • Effect of vibration on skin blood flow in an in vivo microcirculatory model（2008/04 BioScience Trends）
  • Oxygen consumption of keloids and hypertrophic scars（2008/04 Ann Plast Surg）
  • A technique to visualize wound bed microcirculation and the acute effect of negative pressure（2008/04 Wound Repair Regen）
  • Feasibility study on driver's stress detection from differential skin temperature measurement（2008/04 IEEE Eng Med Biol Soc）
  • Physiological role of nitric oxide in oxygen consumption by arteriolar wall（2008/04 IEEE Eng Med Biol Soc）
  • Vasodilation of intramuscular arterioles under shear stress in dystrophin-deficient skeletal muscle is impaired through decreased nNOS expression（2008/04 Acta Myol）
  • Compact capillaroscopy for human skin using CCD video-probe（2007/04 Microvascular Reviews and Communications）
  • Alpha V beta 3 (αvβ3) integrin inhibition reduces leukocyte-endothelium interaction in a pressure-induced reperfusion model（2007/04 Wound Rep Reg 15）
  • Vascular wall energetics in arterioles during nitric oxide dependent and independent vasodilation（2006/04 J Appl Physiol）
  • Impaired flow- dependent control of vascular tone and remodeling in P2X4-deficient mice.（2006/04 Nat Med）
  • Efficacy of a skin-protection power for use as a dressing for intractable ulcers（2006/04 J Wound Care）
  • Arterioles' contribution to oxygen supply to skeletal muscles at rest（2006/04 Eur J Appl Physiol）
  • Sprouting from arteriovenous shunt vessels with increased blood flow（2005/04 Med Biol Eng Comput）
  • Non-linear regulation of capillary perfusion in relation to ambient pO2 changes in skeletal muscle（2005/04 Eur J Appl Physiol）
  • Evaluating dressing materials for the prevention of shear force in the treatment of pressure ulcers（2005/04 J Wound Care）
  • Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle（2005/04 Am J Physiol Heart Circ Physiol）
  • Nitric oxide modulates oxygen consumption by arteriolar walls in rat skeletal muscle.（2005/04 Am J Physiol. Heart Circ Physiol）
  • Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system（2004/04 Free Radic Biol Med）
  • A symmetrical dorsal island double flap in the mouse（2004/04 Eur J Plast Surg）
  • Bone marrow cell implantation improves flap viability after ischemia-reperfusion injury（2004/04 Ann Plast Surg）
  • Global analysis of shear stress-responsive genes in vascular endothelial cells（2003/04 J Atheroscler Thromb）
  • Skin temperature changes induced by strong static magnetic field exposure（2003/04 Bioelectromagnetics）
  • Regenerative surgery for sacral pressure ulcers using collagen matrix substitute dermis (artificial dermis)（2003/04 Ann Plast Surg）
  • Dorsal bipedicled island skin flap: a new flap model in mice（2002/04 Scand J Plast Reconstr Surg Hand Surg）
  • Effect of hyperthermic preconditioning on the survival of ischemia-reperfused skin flaps（2002/04 J Reconstructive Microsurgery）
  • In vivo model for visualizing flap microcirculation of ischemia-reprfusion（2002/04 Microsurgery）
  • Microvascular and interstitial pO2 measurements in rat skeletal muscle by phosphorescence quenching（2001/04 J Appl Physiol）
  • High-intensity magnetic fields modulate skin microcirculation and temperature in vivo（2000/04 Bioelectromagnetics）
  • Dual-beam laser illuminator of fluorescence microscope for in vivo microcirculation studies（1999/08 Med Biol Eng Comput）
  • Biological effects of magnetic fields on the microcirculatory blood flow in vivo: A preliminary report（1998/08 Med Biol Eng Comput）
  • In vivo measurement of morphometric hemodynamic changes in the microcirculation during angiogenesis under chronic 1-adrenergic blocker treatment（1998/08 Microvasc Res）
  • Amrinone, a selective phosphodiesterase III inhibitor, improves microcirculation and flap survival: a comparative study with prostaglandin E1（1998/08 J Surg Res）
  • Endothelium- and cytochrome P-450-dependent relaxation induced by isoproterenol in rat aortic rings（1997/08 Eur J Pharmacol）
  • Effect of shear stress on wound-healing angiogenesis in the rabbit ear chamber（1997/08 J Surg Res）
  • The involvement of KCa, KATP and Kv channels in vasorelaxing responses to acetylcholine in rat aortic rings（1997/08 Gen Pharmacol）
  • Mechanism of macromolecule concentration in collecting lymphatics in rat mesentery（1997/05 Microvasc Res）
  • The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by 1- and 2-adrenoceptor activation in rat aortic rings（1996/08 Brit J Pharmacol）
  • A new fluorescence microscopy for tomographic observation of microcirculation by using dual beam slit laser illumination（1995/08 Microvasc Res）
  • Capillary-tissue arrangement in the skeletal muscle optimized for oxygen transport in all mammals（1995/08 Microvasc Res）
  • Blood flow dependence of local capillary permeability of Cr-EDTA in the rabbit skeletal muscle（1992/08 Jpn J Physiol）
  • Measurement of local capillary permeability in skeletal muscle by microscopic clearance method（1991/08 Jpn J Physiol）
  • Pressure-volume relationships of finger arteries in healthy subjects and patients with coronary atherosclerosis measured non-invasively by photoelectric plethysmography（1991/04 Jpn Circ J）
  • The efficiency of the vascular-tissue system for oxygen transport in the skeletal muscle（1990/04 Microvasc Res）
  • Roles of fluid shear stress in physiological regulation of vascular structure and function（1988/04 Biorheology）
  • Oxygen transport to tissue during recurrent blood flow supply by grouped capillaries in skeletal muscle with or without facilitated diffusion（1987/04 Advances in Experimental Medicine & Biology）
  • Optimum capillary number for oxygen delivery to tissue in man（1987/04 Bull math Biol）
  • Step response analyses of the cardiovascular system and their application to the measurement of systemic and pulmonary vein compliances（1986/04 Heart Vessels）
  • Effects of intermittent capillary flow on oxygen transport in skeletal muscle studied by dynamic computer simulation（1985/04 Advances in Experimental Medicine & Biology）
  • Microcirculatory responses to carotid sinus nerve stimulation at various ambient O2 tension in the rabbit tenuissimus muscle（1985/04 Microvasc Res）
  • New oscillometric method for indirect measurement of systolic and mean arterial pressure in the human finger, Part 1; model experiment（1982/04 Med Biol Eng Comput）
  • New oscillometric method for indirect measurement of systolic and mean arterial pressure in the human finger, Part 2; correlation study（1982/04 Med Biol Eng Comput）